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First-of-its-kind trial finds psychedelic microdosing is equal to placebo

by EmpathiCSubstanceS | Apr 25, 2021 | Addiction, Anxiety, Depression, Microdosing

A first of its kind “self-blinded” trial testing the effect of psychedelic microdosing has found the anecdotally popular practice may be an example of a strong placebo effect. The research, led by Imperial College London, suggests there is little...

First head-to-head trial pits psychedelic therapy against antidepressant

by EmpathiCSubstanceS | Apr 25, 2021 | Addiction, Anxiety, Depression

A first-of-its-kind clinical trial has pitted a common antidepressant against psilocybin, the main psychedelic compound found in magic mushrooms. The results, recently published in the New England Journal of Medicine, are decidedly mixed with the primary depression...

Mice tripping on psychedelics help explain neural origins of hallucinations

by EmpathiCSubstanceS | Nov 10, 2020 | Addiction, Alcoholism, Anxiety

A new study is helping clarify what is going on in our brains when we hallucinate. To do this, researchers from the University of Oregon dosed mice with a powerful psychedelic drug and with unprecedented detail zoomed in on how the animal’s brains subsequently...

Psychedelic research on microdosing rats with DMT reveals unusual results

by EmpathiCSubstanceS | Nov 10, 2020 | Pain

In a first-of-its-kind study, a team of researchers from the University of California, Davis has examined the effects of psychedelic microdosing on animal behavior. The results yielded a variety of unexpected effects including some surprising negative changes...

How psychedelic DMT promotes the production of new brain cells

by EmpathiCSubstanceS | Nov 10, 2020 | Pain

New research suggests the potential for psychedelic drugs to stimulate new neuron production may be able to be separated from the drugs’ hallucinogenic effects. Robust new research, published in the journal Translational Psychiatry, is reporting on several years...
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Psychedelic Research

5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) used in a naturalistic group setting is associated with unintended improvements in depression and anxiety

Aug 11, 2022

Of those reporting having been diagnosed with depression (41%) or anxiety (48%), most reported these conditions were improved (depression=80%; anxiety=79%) following 5-MeO-DMT use, and fewer reported they were unchanged (depression=17%; anxiety=19%) or worsened...

Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases

Aug 11, 2022

At the 2-month follow-up, positive trends were found via the State-Trait Anxiety Inventory (STAI) in reductions in trait anxiety (p = 0.033) with an effect size of 1.1, and state anxiety was significantly reduced (p = 0.021) with an effect size of 1.2, with no acute...

Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial

Aug 11, 2022

High-dose psilocybin produced large decreases in clinician- and self-rated measures of depressed mood and anxiety, along with increases in quality of life, life meaning, and optimism, and decreases in death anxiety. At 6-month follow-up, these changes were sustained,...

Psychedelic Medicine

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