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California bill proposes lawful use and sharing of psychedelic drugs

by EmpathiCSubstanceS | Apr 25, 2021 | Addiction, Cannabis Marijuana

A broad drug reform bill has been introduced to the California state legislature proposing to decriminalize the possession and personal use of a number of psychedelic drugs, including LSD, psilocybin and MDMA. The bill proposes to expunge all criminal convictions...

MDMA proves a promising alcoholism treatment in world-first trial

by EmpathiCSubstanceS | Apr 25, 2021 | Addiction, Alcoholism

A new study published in the Journal of Psychopharmacology is reporting on a landmark clinical trial exploring the potential for MDMA-assisted psychotherapy in treating subjects with alcohol use disorder. The small open-label trial is the first to test MDMA therapy as...

First-of-its-kind trial finds psychedelic microdosing is equal to placebo

by EmpathiCSubstanceS | Apr 25, 2021 | Addiction, Anxiety, Depression, Microdosing

A first of its kind “self-blinded” trial testing the effect of psychedelic microdosing has found the anecdotally popular practice may be an example of a strong placebo effect. The research, led by Imperial College London, suggests there is little...

First head-to-head trial pits psychedelic therapy against antidepressant

by EmpathiCSubstanceS | Apr 25, 2021 | Addiction, Anxiety, Depression

A first-of-its-kind clinical trial has pitted a common antidepressant against psilocybin, the main psychedelic compound found in magic mushrooms. The results, recently published in the New England Journal of Medicine, are decidedly mixed with the primary depression...

Mice tripping on psychedelics help explain neural origins of hallucinations

by EmpathiCSubstanceS | Nov 10, 2020 | Addiction, Alcoholism, Anxiety

A new study is helping clarify what is going on in our brains when we hallucinate. To do this, researchers from the University of Oregon dosed mice with a powerful psychedelic drug and with unprecedented detail zoomed in on how the animal’s brains subsequently...
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Psychedelic Research

Neurosciences and psychotherapeutic applications in the psychedelic research renaissance

Aug 11, 2022

Psilocybin, a 5-HT2A receptor agonist has been associated with reduced activity in the Default- Mode Network (commonly activated during introspection and self-reflection), enhanced access to biographical memories, positive emotional attentional bias and a reduction on...

Altered Insula Connectivity under MDMA

Aug 11, 2022

Results revealed decreased right insula/salience network functional connectivity under MDMA. Furthermore, these decreases in right insula/salience network connectivity correlated with baseline trait anxiety and acute experiences of altered bodily sensations under...

Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression

Aug 11, 2022

For the interaction of OBN and DED with Time (QIDS-SR as dependent variable), the main effect and the effects at each time point compared to baseline were all significant (p = 0.002 and p = 0.003, respectively, for main effects), confirming our main hypothesis....

Psychedelic Medicine

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