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Looking Back: A brief history of psychedelic psychiatry

by EmpathiCSubstanceS | Feb 2, 2022 | Bipolar Disorder, LSD, MDMA Sassafras Molly, OCD, Pain, Psilocybin Magic Mushroom

On 5 May 1953 the novelist Aldous Huxley dissolved four-tenths of a gram of mescaline in a glass of water, drank it, then sat back and waited for the drug to take effect. Huxley consumed the drug in his California home under the direct supervision of psychiatrist...

Is the Phase 3 Trial Data for MDMA Therapy sets Path for FDA Approval?

by EmpathiCSubstanceS | Jan 14, 2022 | Neuropathy, NN-Dimethyltryptamine, OCD, San Pedro Mescaline

The first results from Phase 3 trials testing MDMA-assisted psychotherapy for post-traumatic stress disorder (PTSD) have been announced. The extremely promising data are the first Phase 3 results to be revealed for any psychedelic-based therapy, paving the way for a...

Taking Psychedelics doesn’t Make You a Better or More Peaceful Person.

by EmpathiCSubstanceS | Jan 14, 2022 | LSD, MDMA Sassafras Molly, Microdosing, Neuropathy, NN-Dimethyltryptamine, OCD, Pain, Parkinson's Disease

Another myth being commercialized is that psychedelic drugs will make you a peaceful, righteous human. The notion that the world’s problems would be solved if more people took entheogens is a hallucination in and of itself. However, there are countless examples of...

Beware of Psychedelic Gimmick Investment Ventures.

by EmpathiCSubstanceS | Jan 14, 2022 | Addiction, Alcoholism, Anxiety, Ayahuasca, Bipolar Disorder, Cancer, Cannabis Marijuana, CBC, Chronic Pain

Before you start a psychedelic venture or adventure, keep in mind that there are many psychedelic gimmicks that have long preceded the current “shroom boom.” As Alan Watts is purported to have said, “Anybody who tells you that he has some way of leading you to...

Psychedelics are more than LSD and Mushrooms.

by EmpathiCSubstanceS | Jan 14, 2022 | Cluster Headaches, Depression, DMT, Kambo, LSD

The main focus on naturally occurring psychedelics has been on a few dozen species identified in North and South America. For example, the Western world knows of roughly 100 species of psychedelic mushrooms. Is this a bias from our bioprospecting or a true...
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This community is being designed as a secure space. It is not a place to seek, encourage, or participate in the procurement of controlled substances. Do not bring, buy, sell, transfer, or arrive on any illegal substances, or swap information on how to buy them. Attendees and/or members of this community who violate these basic house rules will be removed from the community and will not be allowed to attend future events.

Psychedelic Research

A qualitative report on the subjective experience of intravenous psilocybin administered in an FMRI environment

Aug 17, 2022

Nine broad categories of phenomenology were identified in the phenomenological analysis of the experience; perceptual changes including visual, auditory and somatosensory distortions, cognitive changes, changes in mood, effects of memory, spiritual or mystical type...

Broadband Cortical Desynchronization Underlies the Human Psychedelic State

Aug 17, 2022

Psilocybin reduced spontaneous cortical oscillatory power from 1 to 50 Hz in posterior association cortices, and from 8 to 100 Hz in frontal association cortices. Large decreases in oscillatory power were seen in areas of the...

Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis

Aug 17, 2022

Here, independent components and seed-based FC analyses revealed increased DMN-TPN FC and so decreased DMN-TPN orthogonality after psilocybin. Increased DMN-TPN FC has been found in psychosis and meditatory states, which share some phenomenological similarities with...

Psychedelic Medicine

What is 5-HT2A receptor?

Mar 8, 2023

The 5-HT2A receptor ("5-HT" = 5-hydroxytryptamine, also known as serotonin) is a widely-expressed Gq-coupled protein receptor (GCPR) that triggers a range of intracellular pathways. Psilocybin and major depression Increased network modularity is a symptom of major...

Does genes impact psychedelic experiences?

Mar 8, 2023

Variations in a crucial receptor’s genetics led to differences in efficacy and potency for four psychedelic drugs. Researchers in North Carolina have found evidence that people’s genes may affect how they trip on psychedelic drugs. The finding may be a potential...

Breakthrough study discovers that psychedelics breach our neurons

Mar 8, 2023

New research shows psychedelics activate receptors inside brain cells that other compounds, like serotonin, cannot. he clinical evidence for using psychedelics to treat major depressive disorder, PTSD, addiction, and other mental health conditions is building. But...

LSD modulates music-induced imagery via changes in Para hippocampal connectivity

Aug 16, 2022

Results revealed increased PHC-visual cortex (VC) functional connectivity and PHC to VC information flow in the interaction between music and LSD. This latter result correlated positively with ratings of enhanced eyes-closed visual imagery, including imagery of an...

New Tools for Depression

Aug 12, 2022

COULD AN OVERACTIVE IMMUNE SYSTEM make you depressed? In the late 1990s, psychiatrist Andrew Miller and his colleagues began to notice that patients with cancer, cardiovascular disease, obesity and Crohn’s disease—all conditions that cause higher than normal levels of...

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