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Why Psychedelic Therapy Research Gets First US Government Funding in Decades?

by EmpathiCSubstanceS | Jan 13, 2022 | Iboga, MDMA Sassafras Molly, Neuropathy, OCD, Parkinson's Disease, Psilocybin Magic Mushroom, San Pedro Mescaline

The latest research into psilocybin therapy as a treatment for tobacco addiction has yielded promising results. Johns Hopkins Medicine was awarded a US$4-million grant by the National Institutes of Health (NIH) to further clinical research investigating...

What Are the Truths and Myths About Psychedelics and Extreme Sports?

by EmpathiCSubstanceS | Jan 13, 2022 | Cannabis Marijuana, Iboga, Kambo, MDMA Sassafras Molly, Microdosing, OCD

One of the most iconic, possibly apocryphal, drug stories of the 20th century is the tale of Pittsburgh Pirates pitcher Dock Ellis throwing a no-hitter while tripping on LSD in 1970. Ellis recounted his story in great detail to NPR shortly before his death, and the...

Is Microdosing Considered a Sport Performance-Enhancing?

by EmpathiCSubstanceS | Jan 13, 2022 | Iboga, LSD, MDMA Sassafras Molly, Microdosing, Neuropathy, NN-Dimethyltryptamine, OCD, Psilocybin Magic Mushroom

With scientists now beginning to investigate the popular phenomenon of microdosing there are only anecdotes and reports from citizen scientists offering insights into the possible performance-enhancing effect of this behavior. The few published studies on microdosing...

What are You Hoping to Get Out of your Psychedelic Experience?

by EmpathiCSubstanceS | Jan 13, 2022 | Iboga, Kambo, LSD, MDMA Sassafras Molly, Microdosing

An often overlooked part of planning a psychedelic experience is considerations for what you are going to do afterwards. If you are taking psychedelics in a location that involves driving how are you going to get home? Do you have a designated driver? Aftercare and...

Why Set and Setting Are Crucial to Experience Psychedelics?

by EmpathiCSubstanceS | Jan 13, 2022 | Iboga, LSD, MDMA Sassafras Molly, Microdosing, Pain, Psilocybin Magic Mushroom

Set and setting are terms used to describe the internal and external environment that is occupied during an altered state experience. The set and setting can have a huge effect on the overall experience. Setting is the physical place where an altered state occurs....
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This community is being designed as a secure space. It is not a place to seek, encourage, or participate in the procurement of controlled substances. Do not bring, buy, sell, transfer, or arrive on any illegal substances, or swap information on how to buy them. Attendees and/or members of this community who violate these basic house rules will be removed from the community and will not be allowed to attend future events.

Psychedelic Research

A qualitative report on the subjective experience of intravenous psilocybin administered in an FMRI environment

Aug 17, 2022

Nine broad categories of phenomenology were identified in the phenomenological analysis of the experience; perceptual changes including visual, auditory and somatosensory distortions, cognitive changes, changes in mood, effects of memory, spiritual or mystical type...

Broadband Cortical Desynchronization Underlies the Human Psychedelic State

Aug 17, 2022

Psilocybin reduced spontaneous cortical oscillatory power from 1 to 50 Hz in posterior association cortices, and from 8 to 100 Hz in frontal association cortices. Large decreases in oscillatory power were seen in areas of the...

Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis

Aug 17, 2022

Here, independent components and seed-based FC analyses revealed increased DMN-TPN FC and so decreased DMN-TPN orthogonality after psilocybin. Increased DMN-TPN FC has been found in psychosis and meditatory states, which share some phenomenological similarities with...

Psychedelic Medicine

What is 5-HT2A receptor?

Mar 8, 2023

The 5-HT2A receptor ("5-HT" = 5-hydroxytryptamine, also known as serotonin) is a widely-expressed Gq-coupled protein receptor (GCPR) that triggers a range of intracellular pathways. Psilocybin and major depression Increased network modularity is a symptom of major...

Does genes impact psychedelic experiences?

Mar 8, 2023

Variations in a crucial receptor’s genetics led to differences in efficacy and potency for four psychedelic drugs. Researchers in North Carolina have found evidence that people’s genes may affect how they trip on psychedelic drugs. The finding may be a potential...

Breakthrough study discovers that psychedelics breach our neurons

Mar 8, 2023

New research shows psychedelics activate receptors inside brain cells that other compounds, like serotonin, cannot. he clinical evidence for using psychedelics to treat major depressive disorder, PTSD, addiction, and other mental health conditions is building. But...

LSD modulates music-induced imagery via changes in Para hippocampal connectivity

Aug 16, 2022

Results revealed increased PHC-visual cortex (VC) functional connectivity and PHC to VC information flow in the interaction between music and LSD. This latter result correlated positively with ratings of enhanced eyes-closed visual imagery, including imagery of an...

New Tools for Depression

Aug 12, 2022

COULD AN OVERACTIVE IMMUNE SYSTEM make you depressed? In the late 1990s, psychiatrist Andrew Miller and his colleagues began to notice that patients with cancer, cardiovascular disease, obesity and Crohn’s disease—all conditions that cause higher than normal levels of...

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