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User perceptions of the benefits and harms of hallucinogenic drug use: A web-based questionnaire study

by EmpathiCSubstanceS | Aug 17, 2022 | LSD, Psychedelic Research

A wide-range of benefits was reported, including: help with mood disorders, addictions and migraine as well as more general long-term improvements in wellbeing. Symptoms of hallucinogen persisting perceptual disorder were reported by a number of subjects and these...

Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD

by EmpathiCSubstanceS | Aug 17, 2022 | LSD, Psychedelic Research

We found that LSD alters the energy and the power of individual harmonic brain states in a frequency-selective manner. Remarkably, this leads to an expansion of the repertoire of active brain states, suggestive of a general re-organization of brain dynamics given the...

Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution

by EmpathiCSubstanceS | Aug 17, 2022 | LSD, Psychedelic Research

High-level association cortices (partially overlapping with the default-mode, salience, and frontoparietal attention networks) and the thalamus showed increased global connectivity under the drug. The cortical areas showing increased global connectivity overlapped...

LSD modulates effective connectivity and neural adaptation mechanisms in an auditory oddball paradigm

by EmpathiCSubstanceS | Aug 17, 2022 | LSD, Psychedelic Research

Dynamic causal modelling revealed that both the presentation of novel stimuli and LSD modulate backward extrinsic connectivity within a task-activated fronto-temporal network, as well as intrinsic connectivity in the primary auditory cortex. These findings show...

LSD alters eyes-closed functional connectivity within the early visual cortex in a retinotopic fashion

by EmpathiCSubstanceS | Aug 17, 2022 | LSD, Psychedelic Research

Consistent with our prior hypothesis, the difference between RSFC of patches with congruent retinotopic specificity (horizontal-horizontal and vertical-vertical) and those with incongruent specificity (horizontal-vertical and vertical-horizontal) increased...
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This community is being designed as a secure space. It is not a place to seek, encourage, or participate in the procurement of controlled substances. Do not bring, buy, sell, transfer, or arrive on any illegal substances, or swap information on how to buy them. Attendees and/or members of this community who violate these basic house rules will be removed from the community and will not be allowed to attend future events.

Psychedelic Research

MDMA-assisted psychotherapy for posttraumatic stress disorder in military veterans, firefighters, and police officers: a randomized, double-blind, dose-response, phase 2 clinical trial

Aug 17, 2022

Between Nov 10, 2010, and Jan 29, 2015, 26 veterans and first responders met eligibility criteria and were randomly assigned to receive 30 mg (n=7), 75 mg (n=7), or 125 mg (n=12) of MDMA plus psychotherapy. At the primary endpoint, the 75 mg and 125 mg groups had...

A randomized, controlled pilot study of MDMA-assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD)

Aug 17, 2022

We found that MDMA-assisted psychotherapy can be safely administered in a clinical setting. No drug-related serious adverse events occurred. We did not see statistically significant reductions in CAPS scores (p = 0.066), although there was clinically and statistically...

The Entropic Brain: A Theory of Conscious States Informed by Neuroimaging Research with Psychedelic Drugs

Aug 17, 2022

Based on neuroimaging data with psilocybin, a classic psychedelic drug, it is argued that the defining feature of ‘primary states’ is elevated entropy in certain aspects of brain function, such as the repertoire of functional connectivity motifs that form and fragment...

Psychedelic Medicine

Do we need a mystical experience to have the healing effect?

Jan 1, 2024

The sense of oneness with the universe around you, ego transcendence, feeling that this other reality is more real than your waking reality. It’s certainly the best, most replicated thing in science that if you have the mystical experience during the psychedelic...

Psychedelic versus SSRI

Jan 1, 2024

The standard antidepressants, we know what they do. Brain imaging studies show they very rapidly turn down the danger center in the brain. So you wander around for a few weeks, feel better about things, you smile a little bit more, and then people smile back at you....

What It’s Like to Take a Psychedelic Trip

Jan 1, 2024

It doesn’t take a third eye to see that, at long last, Americans seem primed to turn on. If you’ve heard yourself utter the phrase “plant medicine” when what you mean is “shrooms,” if you’ve found yourself absently Googling “ayahuasca retreats” the way you used to...

Why Psychedelics Are Popular Now

Dec 8, 2023

Has anyone else noticed that health and wellness has become hip? Instead of the old tropes such as football players not trying in school and partying until you are sick made someone popular, now environmental awareness, treating your body as a temple and expanding...

Pineal Gland and DMT (Dimethyltryptamine)

Sep 2, 2023

In the past few years, thrill-seekers from Hollywood, Silicon Valley and beyond have been travelling to South America to take part in so-called Ayahuasca retreats. Their goal: to partake in a brewed concoction made from a vine plant Banisteriopsis caapi, traditionally...

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