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Increased amygdala responses to emotional faces after psilocybin for treatment-resistant depression

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

Group results revealed rapid and enduring improvements in depressive symptoms post psilocybin. Increased responses to fearful and happy faces were observed in the right amygdala post-treatment, and right amygdala increases to fearful versus neutral faces were...

Psilocybin with psychological support for treatment-resistant depression: six-month follow-up

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

Treatment was generally well tolerated. Relative to baseline, marked reductions in depressive symptoms were observed for the first 5 weeks post-treatment (Cohen’s d = 2.2 at week 1 and 2.3 at week 5, both p < 0.001); nine and four patients met the criteria...

Patients’ Accounts of Increased “Connectedness” and “Acceptance” After Psilocybin for Treatment-Resistant Depression

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

Two main change processes were identified in relation to the treatment. The first concerned change from disconnection (from self, others, and world) to connection, and the second concerned change from avoidance (of emotion) to acceptance. A third theme concerned...

Psilocybin for treatment-resistant depression: FMRI-measured brain mechanisms

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

Decreased depressive symptoms were observed in all 19 patients at 1-week post-treatment and 47% met criteria for response at 5 weeks. Whole-brain analyses revealed post-treatment decreases in CBF in the temporal cortex, including the amygdala. Decreased amygdala CBF...

What are selective serotonin reuptake inhibitor SSRIs antidepressants

by EmpathiCSubstanceS | Aug 4, 2022 | Addiction, Anxiety, Ayahuasca, Bipolar Disorder, Chronic Pain, MDMA Sassafras Molly, Psychedelic Medicine, Psychotropics

Serotonin is one of the chemical messengers (neurotransmitters) that carry signals between brain nerve cells (neurons). SSRIs block the reabsorption (reuptake) of serotonin into neurons. This makes more serotonin available to improve transmission of messages between...
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Psychedelic Research

A qualitative report on the subjective experience of intravenous psilocybin administered in an FMRI environment

Aug 17, 2022

Nine broad categories of phenomenology were identified in the phenomenological analysis of the experience; perceptual changes including visual, auditory and somatosensory distortions, cognitive changes, changes in mood, effects of memory, spiritual or mystical type...

Broadband Cortical Desynchronization Underlies the Human Psychedelic State

Aug 17, 2022

Psilocybin reduced spontaneous cortical oscillatory power from 1 to 50 Hz in posterior association cortices, and from 8 to 100 Hz in frontal association cortices. Large decreases in oscillatory power were seen in areas of the...

Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis

Aug 17, 2022

Here, independent components and seed-based FC analyses revealed increased DMN-TPN FC and so decreased DMN-TPN orthogonality after psilocybin. Increased DMN-TPN FC has been found in psychosis and meditatory states, which share some phenomenological similarities with...

Psychedelic Medicine

What is 5-HT2A receptor?

Mar 8, 2023

The 5-HT2A receptor ("5-HT" = 5-hydroxytryptamine, also known as serotonin) is a widely-expressed Gq-coupled protein receptor (GCPR) that triggers a range of intracellular pathways. Psilocybin and major depression Increased network modularity is a symptom of major...

Does genes impact psychedelic experiences?

Mar 8, 2023

Variations in a crucial receptor’s genetics led to differences in efficacy and potency for four psychedelic drugs. Researchers in North Carolina have found evidence that people’s genes may affect how they trip on psychedelic drugs. The finding may be a potential...

Breakthrough study discovers that psychedelics breach our neurons

Mar 8, 2023

New research shows psychedelics activate receptors inside brain cells that other compounds, like serotonin, cannot. he clinical evidence for using psychedelics to treat major depressive disorder, PTSD, addiction, and other mental health conditions is building. But...

LSD modulates music-induced imagery via changes in Para hippocampal connectivity

Aug 16, 2022

Results revealed increased PHC-visual cortex (VC) functional connectivity and PHC to VC information flow in the interaction between music and LSD. This latter result correlated positively with ratings of enhanced eyes-closed visual imagery, including imagery of an...

New Tools for Depression

Aug 12, 2022

COULD AN OVERACTIVE IMMUNE SYSTEM make you depressed? In the late 1990s, psychiatrist Andrew Miller and his colleagues began to notice that patients with cancer, cardiovascular disease, obesity and Crohn’s disease—all conditions that cause higher than normal levels of...

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