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Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

High-dose psilocybin produced large decreases in clinician- and self-rated measures of depressed mood and anxiety, along with increases in quality of life, life meaning, and optimism, and decreases in death anxiety. At 6-month follow-up, these changes were sustained,...

Reduction in social anxiety after MDMA-assisted psychotherapy with autistic adults: a randomized, double-blind, placebo-controlled pilot study

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

Improvement in LSAS scores from baseline to the primary endpoint was significantly greater for MDMA group compared to the placebo group (P = 0.037), and placebo-subtracted Cohen’s d effect size was very large (d = 1.4, CI − 0.074, 2.874). Change in LSAS scores from...

What are selective serotonin reuptake inhibitor SSRIs antidepressants

by EmpathiCSubstanceS | Aug 4, 2022 | Addiction, Anxiety, Ayahuasca, Bipolar Disorder, Chronic Pain, MDMA Sassafras Molly, Psychedelic Medicine, Psychotropics

Serotonin is one of the chemical messengers (neurotransmitters) that carry signals between brain nerve cells (neurons). SSRIs block the reabsorption (reuptake) of serotonin into neurons. This makes more serotonin available to improve transmission of messages between...

How to have a safe psychedelic Journey?

by EmpathiCSubstanceS | Jul 11, 2022 | Ayahuasca, Bipolar Disorder, Cancer, Iboga, Kambo, MDMA Sassafras Molly, Psychedelic Medicine, Psychotropics

Remember that psychedelic substances are illegal in most jurisdictions. If you have physical or mental health issues, speak to a mental health professional before experimenting with psychedelics. Ensure you are in a physically safe, controlled environment. Always...

Which Are Natural Psychedelics?

by EmpathiCSubstanceS | Jul 5, 2022 | Ayahuasca, Iboga, Kambo, LSD, Psychedelic Medicine, Psychotropics, PTSD, San Pedro Mescaline

What are the most common natural psychedelics? The natural world is full of psychedelic and other psychoactive substances. In fact, most synthetic psychedelics are derived or inspired by naturally-occurring substances. Many natural psychedelics are considered...
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Psychedelic Research

Double-blind comparison of the two hallucinogens psilocybin and dextromethorphan: effects on cognition

Aug 17, 2022

Global cognitive impairment, assessed using the Mini-Mental State Examination during peak drug effects, was not observed with psilocybin or DXM. Orderly and dose-dependent effects of psilocybin were observed on psychomotor performance, working memory, episodic memory,...

validation of the revised Mystical Experience Questionnaire in experimental sessions with psilocybin

Aug 17, 2022

Results of confirmatory factor analysis demonstrate the reliability and internal validity of the MEQ30. Structural equation models demonstrate the external and convergent validity of the MEQ30 by showing that latent variable scores on the MEQ30 positively predict...

The effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers

Aug 17, 2022

Between-network RSFC was generally increased under psilocybin, implying that networks become less differentiated from each other in the psychedelic state. Decreased RSFC between visual and sensorimotor RSNs was also observed. MDMA had a notably less marked effect on...

Psychedelic Medicine

A Trip to Therapy

Aug 12, 2022

THE EXAMINATION ROOMS IN THE BLUESTON CENTER FOR CLINICAL RESEARCH at the New York University College of Dentistry are exactly what you might expect of a facility that conducts trials of dental and medical therapies. There are reclining exam chairs, linoleum floors,...

Psychedelic Research in 2022

Aug 12, 2022

During his decades as Massachusetts General Hospital’s Chief of Psychiatry, Jerry Rosenbaum observed that patients suffering from a range of mental illnesses would sometimes get stuck in a state of rumination, or unceasing cycles of unpleasant, self-deprecating...

More Realistic Forecasting of Future Life Events After Psilocybin for Treatment-Resistant Depression

Aug 11, 2022

Patients showed a significant pessimism bias at baseline [t(14) = -3.260, p = 0.006; 95% CI (-0.16, -0.03), g = 1.1] which was related to the severity of their depressive symptoms (rs = -0.55, p = 0.017). One week after psilocybin treatment, this bias was...

Max Weber – The disenchantment of modern life.

Aug 5, 2022

Max Weber - The disenchantment of modern life. He believed that since the Enlightenment, science and reason had eroded the sway of religion, spirituality, superstition and magic such that transcendent values had become increasingly unavailable to many, especially in...

What are selective serotonin reuptake inhibitor SSRIs antidepressants

Aug 4, 2022

Serotonin is one of the chemical messengers (neurotransmitters) that carry signals between brain nerve cells (neurons). SSRIs block the reabsorption (reuptake) of serotonin into neurons. This makes more serotonin available to improve transmission of messages between...

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