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Psychedelics not linked to mental health problems or suicidal behavior: A population study

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

After adjusting for sociodemographics, other drug use and childhood depression, we found no significant associations between lifetime use of psychedelics and increased likelihood of past year serious psychological distress, mental health treatment, suicidal thoughts,...

Powerful substances in tiny amounts: An interview study of psychedelic microdosing

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

Respondents tended to experiment with microdosing in phases, reporting mostly positive consequences from this form of drug use. Reported effects included improved mood, cognition, and creativity, which often served to counteract symptoms especially from conditions of...

Neurosciences and psychotherapeutic applications in the psychedelic research renaissance

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

Psilocybin, a 5-HT2A receptor agonist has been associated with reduced activity in the Default- Mode Network (commonly activated during introspection and self-reflection), enhanced access to biographical memories, positive emotional attentional bias and a reduction on...

Altered Insula Connectivity under MDMA

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

Results revealed decreased right insula/salience network functional connectivity under MDMA. Furthermore, these decreases in right insula/salience network connectivity correlated with baseline trait anxiety and acute experiences of altered bodily sensations under...

Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

For the interaction of OBN and DED with Time (QIDS-SR as dependent variable), the main effect and the effects at each time point compared to baseline were all significant (p = 0.002 and p = 0.003, respectively, for main effects), confirming our main hypothesis....
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This community is being designed as a secure space. It is not a place to seek, encourage, or participate in the procurement of controlled substances. Do not bring, buy, sell, transfer, or arrive on any illegal substances, or swap information on how to buy them. Attendees and/or members of this community who violate these basic house rules will be removed from the community and will not be allowed to attend future events.

Psychedelic Research

Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose–effect study

Aug 17, 2022

PY dose dependently increased scores of all 5D-ASC core dimensions. Only one subject reacted with transient anxiety to HD PY. Compared with PL, MD and HD PY led to a 50% reduction of performance in the FAIR test. "General inactivation", "emotional excitability", and...

Altered trajectories in the dynamical repertoire of functional network states under psilocybin

Aug 17, 2022

We found that a FC state closely corresponding to the fronto-parietal control system was strongly destabilized in the psychedelic state, while transitions toward a globally synchronized FC state were enhanced. These differences between brain state trajectories in...

Neuroticism is associated with challenging experiences with psilocybin mushrooms

Aug 17, 2022

CEQ scores were negatively associated with emotional stability scores (the inverse of neuroticism) in Study 1 and positively associated with neuroticism scores in Study 2. Neuroticism may contribute to the strength of challenging experiences with psychedelics in...

Psychedelic Medicine

Psychedelic Use Statistics

Sep 2, 2023

With scientific progress marching on and psychedelic use among adults exploding, the need for creating infrastructure and delivering safe and legal access is already upon us. Recently published data from the annual Monitoring the Future (MTF) survey by the National...

Neuroplasticity Explained

Sep 2, 2023

A quarter of the world’s population is estimated to be affected by mental health or neurological challenges in their lifetime. In 2014, approximately 20% of U.S. adults had a mental illness and 22.5 million Americans aged 12 or older were in need of treatment for...

Mental Health Treatment Options

Sep 2, 2023

A quarter of the world’s population is estimated to be affected by mental health or neurological challenges in their lifetime. In 2014, approximately 20% of U.S. adults had a mental illness and 22.5 million Americans aged 12 or older were in need of treatment for...

Improving the End of Life Experience with Entheogens

Sep 2, 2023

:::In a 2019 study, 55% of families felt their loved one had a “bad death.” By igniting a movement to spark conversations and ask the right questions, we create opportunities for the things people most want – including spending time with those they love, dignity, and...

Veterans’ Psychedelic-Assisted Therapy

Sep 2, 2023

Psychedelic-Assisted Therapy is “a form of treatment that uses a group of substances that temporarily alter perception and mood and may impact numerous cognitive processes.” (Source: Evidence Brief: Psychedelic Medications for Mental Health and Substance Use...

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