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Ayahuasca: Pharmacology, neuroscience and therapeutic potential

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

Based on the available evidence, we conclude that ayahuasca shows promise as a therapeutic tool by enhancing self-acceptance and allowing safe exposure to emotional events. We postulate that ayahuasca could be of use in the treatment of impulse-related, personality...

MDMA-assisted psychotherapy for PTSD: Are memory reconsolidation and fear extinction underlying mechanisms?

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

In summary, this review has provided evidence that the beneficial synergistic effects of MDMA with psychotherapy are attributed, at least in part, to the complex neuropharmacological profile of this entactogen creating a neural setting primed to facilitate new...

Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose–effect study

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

PY dose dependently increased scores of all 5D-ASC core dimensions. Only one subject reacted with transient anxiety to HD PY. Compared with PL, MD and HD PY led to a 50% reduction of performance in the FAIR test. “General inactivation”, “emotional...

Safety, Tolerability, and Efficacy of Psilocybin in 9 Patients With Obsessive-Compulsive Disorder

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

One subject experienced transient hypertension without relation to anxiety or somatic symptoms, but no other significant adverse effects were observed. Marked decreases in OCD symptoms of variable degrees were observed in all subjects during 1 or more of the testing...

Replication and extension of a model predicting response to psilocybin

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

This study replicated the previous model, finding a state of surrender before ingestion a key predictor of optimal experience and preoccupation a key predictor of adverse experience. Additional predictors added to the explanatory power for optimal and adverse...
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This community is being designed as a secure space. It is not a place to seek, encourage, or participate in the procurement of controlled substances. Do not bring, buy, sell, transfer, or arrive on any illegal substances, or swap information on how to buy them. Attendees and/or members of this community who violate these basic house rules will be removed from the community and will not be allowed to attend future events.

Psychedelic Research

MDMA-assisted psychotherapy for posttraumatic stress disorder in military veterans, firefighters, and police officers: a randomized, double-blind, dose-response, phase 2 clinical trial

Aug 17, 2022

Between Nov 10, 2010, and Jan 29, 2015, 26 veterans and first responders met eligibility criteria and were randomly assigned to receive 30 mg (n=7), 75 mg (n=7), or 125 mg (n=12) of MDMA plus psychotherapy. At the primary endpoint, the 75 mg and 125 mg groups had...

A randomized, controlled pilot study of MDMA-assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD)

Aug 17, 2022

We found that MDMA-assisted psychotherapy can be safely administered in a clinical setting. No drug-related serious adverse events occurred. We did not see statistically significant reductions in CAPS scores (p = 0.066), although there was clinically and statistically...

The Entropic Brain: A Theory of Conscious States Informed by Neuroimaging Research with Psychedelic Drugs

Aug 17, 2022

Based on neuroimaging data with psilocybin, a classic psychedelic drug, it is argued that the defining feature of ‘primary states’ is elevated entropy in certain aspects of brain function, such as the repertoire of functional connectivity motifs that form and fragment...

Psychedelic Medicine

Do we need a mystical experience to have the healing effect?

Jan 1, 2024

The sense of oneness with the universe around you, ego transcendence, feeling that this other reality is more real than your waking reality. It’s certainly the best, most replicated thing in science that if you have the mystical experience during the psychedelic...

Psychedelic versus SSRI

Jan 1, 2024

The standard antidepressants, we know what they do. Brain imaging studies show they very rapidly turn down the danger center in the brain. So you wander around for a few weeks, feel better about things, you smile a little bit more, and then people smile back at you....

What It’s Like to Take a Psychedelic Trip

Jan 1, 2024

It doesn’t take a third eye to see that, at long last, Americans seem primed to turn on. If you’ve heard yourself utter the phrase “plant medicine” when what you mean is “shrooms,” if you’ve found yourself absently Googling “ayahuasca retreats” the way you used to...

Why Psychedelics Are Popular Now

Dec 8, 2023

Has anyone else noticed that health and wellness has become hip? Instead of the old tropes such as football players not trying in school and partying until you are sick made someone popular, now environmental awareness, treating your body as a temple and expanding...

Pineal Gland and DMT (Dimethyltryptamine)

Sep 2, 2023

In the past few years, thrill-seekers from Hollywood, Silicon Valley and beyond have been travelling to South America to take part in so-called Ayahuasca retreats. Their goal: to partake in a brewed concoction made from a vine plant Banisteriopsis caapi, traditionally...

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