by EmpathiCSubstanceS | Aug 16, 2022 | LSD, Psychedelic Research
Volunteers gave significantly higher ratings for the CIS (p = 0.018), but not the MIT (p = 0.11), after LSD than placebo. The magnitude of suggestibility enhancement under LSD was positively correlated with trait conscientiousness measured at baseline (p = 0.0005)....
by EmpathiCSubstanceS | Aug 16, 2022 | LSD, Psychedelic Research
LSD reduced associative, but concurrently increased sensory-somatomotor brain-wide and thalamic connectivity. Ketanserin fully blocked the subjective and neural LSD effects. Whole-brain spatial patterns of LSD effects matched 5-HT2A receptor cortical gene expression...
by EmpathiCSubstanceS | Aug 16, 2022 | Psychedelic Research
It is clear that very minute concentrations of N,Ndimethyltryptamine have been detected in the brain, but they are not sufficient to produce psychoactive effects. Alternative explanations are presented to explain how stress and near death can produce altered states of...
by EmpathiCSubstanceS | Aug 16, 2022 | Psychedelic Research
A 3-class model fit best and included low attributions of meaning, spiritual significance, challenge, and insight, (“Low” n=294), High meaning and spiritual significance, and Low challenge and insight, (“High/Low” n=356) and High meaning, spiritual significance,...
by EmpathiCSubstanceS | Aug 16, 2022 | Psychedelic Research
Compared with placebo, DMT markedly reduced oscillatory power in the alpha and beta bands and robustly increased spontaneous signal diversity. Time-referenced analyses revealed close relationships between changes in various aspects of subjective experience and changes...
by EmpathiCSubstanceS | Aug 16, 2022 | Psychedelic Research
Results revealed significant increases in phenomenological features associated with the NDE, following DMT administration compared to placebo. Also, we found significant relationships between the NDE scores and DMT-induced ego-dissolution and mystical-type...
