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LSD modulates effective connectivity and neural adaptation mechanisms in an auditory oddball paradigm

by EmpathiCSubstanceS | Aug 17, 2022 | LSD, Psychedelic Research

Dynamic causal modelling revealed that both the presentation of novel stimuli and LSD modulate backward extrinsic connectivity within a task-activated fronto-temporal network, as well as intrinsic connectivity in the primary auditory cortex. These findings show...

LSD alters eyes-closed functional connectivity within the early visual cortex in a retinotopic fashion

by EmpathiCSubstanceS | Aug 17, 2022 | LSD, Psychedelic Research

Consistent with our prior hypothesis, the difference between RSFC of patches with congruent retinotopic specificity (horizontal-horizontal and vertical-vertical) and those with incongruent specificity (horizontal-vertical and vertical-horizontal) increased...

Semantic activation in LSD: evidence from picture naming

by EmpathiCSubstanceS | Aug 17, 2022 | LSD, Psychedelic Research

Results revealed significant effects of LSD on accuracy and error correction that were consistent with an increased spread of semantic activation under LSD. These results are consistent with a generalized “entropic” effect on the mind. We suggest incorporating direct...

LSD modulates music-induced imagery viachanges in parahippocampal connectivity

by EmpathiCSubstanceS | Aug 17, 2022 | Psychedelic Research

Results revealed increased PHC–visual cortex (VC) functional connectivity and PHC to VC information flow in the interaction between music and LSD. This latter result correlated positively with ratings of enhanced eyes-closed visual imagery, including imagery of an...

LSD modulates music-induced imagery via changes in Para hippocampal connectivity

by EmpathiCSubstanceS | Aug 16, 2022 | LSD, Psychedelic Medicine, Psychedelic Research

Results revealed increased PHC-visual cortex (VC) functional connectivity and PHC to VC information flow in the interaction between music and LSD. This latter result correlated positively with ratings of enhanced eyes-closed visual imagery, including imagery of an...

Serotonergic Psychedelics LSD & Psilocybin Increase the Fractal Dimension of Cortical Brain Activity in Spatial and Temporal Domains

by EmpathiCSubstanceS | Aug 16, 2022 | LSD, Psychedelic Research

The first was the fractal dimension of cortical functional connectivity networks and the second was the fractal dimension of BOLD time-series. We were able to show that both psychedelic drugs significantly increased the fractal dimension of functional connectivity...
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Psychedelic Research

Double-blind comparison of the two hallucinogens psilocybin and dextromethorphan: similarities and differences in subjective experiences

Aug 17, 2022

High doses of both drugs produced similar increases in participant ratings of peak overall drug effect strength, with similar times to maximal effect and time-course. Psilocybin produced orderly dose-related increases on most participant-rated subjective measures...

Long-term follow-up of psilocybin-facilitated smoking cessation

Aug 17, 2022

All 15 participants completed a 12-month follow-up, and 12 (80%) returned for a long-term (≥16 months) follow-up, with a mean interval of 30 months (range = 16-57 months) between target-quit date (i.e., first psilocybin session) and long-term follow-up. At 12-month...

Psilocybin-occasioned mystical-type experience in combination with meditation and other spiritual practices produces enduring positive changes in psychological functioning and in trait measures of prosocial attitudes and behaviors

Aug 17, 2022

Outcomes at 6 months included rates of spiritual practice and persisting effects of psilocybin. Compared with low-dose, high-dose psilocybin produced greater acute and persisting effects. At 6 months, compared with LD-SS, both high-dose groups showed large significant...

Psychedelic Medicine

Are you ready to change your mind?

Jul 21, 2022

For decades, psychedelics have evoked a freewheeling past, calling to mind images of hippie counterculture and swirly neon patterns. Recently, however, psychedelics have become synonymous with serious, forward-looking science. Researchers at renowned institutions are...

How To Change Your Mind

Jul 21, 2022

Based on the book about psychedelic therapy, a new Netflix docu-series prompted another writer to reach out to Pollan — and dig into his own experiences.In late 2012, the best-selling author and journalist Michael Pollan (“The Omnivore’s Dilemma”) was at a dinner...

How to have a safe psychedelic Journey?

Jul 11, 2022

Remember that psychedelic substances are illegal in most jurisdictions. If you have physical or mental health issues, speak to a mental health professional before experimenting with psychedelics. Ensure you are in a physically safe, controlled environment. Always...

Which Are Natural Psychedelics?

Jul 5, 2022

What are the most common natural psychedelics? The natural world is full of psychedelic and other psychoactive substances. In fact, most synthetic psychedelics are derived or inspired by naturally-occurring substances. Many natural psychedelics are considered...

What are the benefits of consuming psilocybin magic mushrooms?

Jul 2, 2022

There are many benefits to consuming psilocybin magic mushrooms, and they have been used in many cultures around the world for thousands of years. Studies have shown “a single dose of psilocybin produced substantial and enduring decreases in depressed mood and anxiety...

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