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Motives and side-effects of microdosing with psychedelics among users

by EmpathiCSubstanceS | Aug 17, 2022 | LSD, Psychedelic Research

In total, 1116 of the respondents were either currently microdosing (79.5%) or microdosed in the past (20.5%). LSD (10 mcg) and psilocybin (0.5 g) were the most commonly used psychedelics with a microdosing frequency between two-to-four times a week. The majority of...

Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD

by EmpathiCSubstanceS | Aug 17, 2022 | LSD, Psychedelic Research

The model identified the causative mechanisms for the non-linear interactions between the neuronal and neurotransmitter system, which are uniquely linked to (1) the underlying anatomical connectivity, (2) the modulation by the specific brain wide distribution of...

Cessation and reduction in alcohol consumption and misuse after psychedelic use

by EmpathiCSubstanceS | Aug 17, 2022 | LSD, Psychedelic Research

343 respondents, mostly White (89%), males (78%), in the USA (60%) completed the survey. Participants reported seven years of problematic alcohol use on average before the psychedelic experience to which they attributed reduced alcohol consumption, with 72% meeting...

User perceptions of the benefits and harms of hallucinogenic drug use: A web-based questionnaire study

by EmpathiCSubstanceS | Aug 17, 2022 | LSD, Psychedelic Research

A wide-range of benefits was reported, including: help with mood disorders, addictions and migraine as well as more general long-term improvements in wellbeing. Symptoms of hallucinogen persisting perceptual disorder were reported by a number of subjects and these...

Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD

by EmpathiCSubstanceS | Aug 17, 2022 | LSD, Psychedelic Research

We found that LSD alters the energy and the power of individual harmonic brain states in a frequency-selective manner. Remarkably, this leads to an expansion of the repertoire of active brain states, suggestive of a general re-organization of brain dynamics given the...

Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution

by EmpathiCSubstanceS | Aug 17, 2022 | LSD, Psychedelic Research

High-level association cortices (partially overlapping with the default-mode, salience, and frontoparietal attention networks) and the thalamus showed increased global connectivity under the drug. The cortical areas showing increased global connectivity overlapped...
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Psychedelic Research

Double-blind comparison of the two hallucinogens psilocybin and dextromethorphan: effects on cognition

Aug 17, 2022

Global cognitive impairment, assessed using the Mini-Mental State Examination during peak drug effects, was not observed with psilocybin or DXM. Orderly and dose-dependent effects of psilocybin were observed on psychomotor performance, working memory, episodic memory,...

validation of the revised Mystical Experience Questionnaire in experimental sessions with psilocybin

Aug 17, 2022

Results of confirmatory factor analysis demonstrate the reliability and internal validity of the MEQ30. Structural equation models demonstrate the external and convergent validity of the MEQ30 by showing that latent variable scores on the MEQ30 positively predict...

The effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers

Aug 17, 2022

Between-network RSFC was generally increased under psilocybin, implying that networks become less differentiated from each other in the psychedelic state. Decreased RSFC between visual and sensorimotor RSNs was also observed. MDMA had a notably less marked effect on...

Psychedelic Medicine

A Trip to Therapy

Aug 12, 2022

THE EXAMINATION ROOMS IN THE BLUESTON CENTER FOR CLINICAL RESEARCH at the New York University College of Dentistry are exactly what you might expect of a facility that conducts trials of dental and medical therapies. There are reclining exam chairs, linoleum floors,...

Psychedelic Research in 2022

Aug 12, 2022

During his decades as Massachusetts General Hospital’s Chief of Psychiatry, Jerry Rosenbaum observed that patients suffering from a range of mental illnesses would sometimes get stuck in a state of rumination, or unceasing cycles of unpleasant, self-deprecating...

More Realistic Forecasting of Future Life Events After Psilocybin for Treatment-Resistant Depression

Aug 11, 2022

Patients showed a significant pessimism bias at baseline [t(14) = -3.260, p = 0.006; 95% CI (-0.16, -0.03), g = 1.1] which was related to the severity of their depressive symptoms (rs = -0.55, p = 0.017). One week after psilocybin treatment, this bias was...

Max Weber – The disenchantment of modern life.

Aug 5, 2022

Max Weber - The disenchantment of modern life. He believed that since the Enlightenment, science and reason had eroded the sway of religion, spirituality, superstition and magic such that transcendent values had become increasingly unavailable to many, especially in...

What are selective serotonin reuptake inhibitor SSRIs antidepressants

Aug 4, 2022

Serotonin is one of the chemical messengers (neurotransmitters) that carry signals between brain nerve cells (neurons). SSRIs block the reabsorption (reuptake) of serotonin into neurons. This makes more serotonin available to improve transmission of messages between...

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