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Psilocybin-Occasioned Mystical Experiences in the Treatment of Tobacco Addiction

by EmpathiCSubstanceS | Aug 17, 2022 | Psilocybin Magic Mushroom, Psychedelic Research

Abstainers scored significantly higher on a measure of psilocybin-occasioned mystical experience. No significant differences in general intensity of drug effects were found between groups, suggesting that mystical-type subjective effects, rather than overall intensity...

Sub-Acute Effects of Psilocybin on Empathy, Creative Thinking, and Subjective Well-Being

by EmpathiCSubstanceS | Aug 17, 2022 | Psychedelic Research

Results indicated that psilocybin enhanced divergent thinking and emotional empathy the morning after use. Enhancements in convergent thinking, valence-specific emotional empathy, and well-being persisted seven days after use. Sub-acute changes in empathy correlated...

Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study

by EmpathiCSubstanceS | Aug 17, 2022 | Psychedelic Research

Participants’ responses to psilocybin were qualitatively similar to those described in other populations. Abstinence did not increase significantly in the first 4 weeks of treatment (when participants had not yet received psilocybin), but increased significantly...

Implications for psychedelic-assisted psychotherapy: Functional magnetic resonance imaging study with psilocybin

by EmpathiCSubstanceS | Aug 17, 2022 | Psilocybin Magic Mushroom, Psychedelic Research

Robust activations to the memories were seen in limbic and striatal regions in the early phase and the medial prefrontal cortex in the late phase in both conditions (P<0.001, whole brain cluster correction), but there were additional visual and other sensory...

Acute Pharmacological Effects of 2C-B in Humans: An Observational Study

by EmpathiCSubstanceS | Aug 17, 2022 | Psychedelic Research, San Pedro Mescaline

Acute administration of 2C-B increased blood pressure and heart rate. Scores of scales related to euphoria increased (high, liking, and stimulated), and changes in perceptions (distances, colors, shapes, and lights) and different body feelings/surrounding were...

Neuroticism is associated with challenging experiences with psilocybin mushrooms

by EmpathiCSubstanceS | Aug 17, 2022 | LSD, Psychedelic Research

CEQ scores were negatively associated with emotional stability scores (the inverse of neuroticism) in Study 1 and positively associated with neuroticism scores in Study 2. Neuroticism may contribute to the strength of challenging experiences with psychedelics in...
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This community is being designed as a secure space. It is not a place to seek, encourage, or participate in the procurement of controlled substances. Do not bring, buy, sell, transfer, or arrive on any illegal substances, or swap information on how to buy them. Attendees and/or members of this community who violate these basic house rules will be removed from the community and will not be allowed to attend future events.

Psychedelic Research

A qualitative report on the subjective experience of intravenous psilocybin administered in an FMRI environment

Aug 17, 2022

Nine broad categories of phenomenology were identified in the phenomenological analysis of the experience; perceptual changes including visual, auditory and somatosensory distortions, cognitive changes, changes in mood, effects of memory, spiritual or mystical type...

Broadband Cortical Desynchronization Underlies the Human Psychedelic State

Aug 17, 2022

Psilocybin reduced spontaneous cortical oscillatory power from 1 to 50 Hz in posterior association cortices, and from 8 to 100 Hz in frontal association cortices. Large decreases in oscillatory power were seen in areas of the...

Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis

Aug 17, 2022

Here, independent components and seed-based FC analyses revealed increased DMN-TPN FC and so decreased DMN-TPN orthogonality after psilocybin. Increased DMN-TPN FC has been found in psychosis and meditatory states, which share some phenomenological similarities with...

Psychedelic Medicine

What is 5-HT2A receptor?

Mar 8, 2023

The 5-HT2A receptor ("5-HT" = 5-hydroxytryptamine, also known as serotonin) is a widely-expressed Gq-coupled protein receptor (GCPR) that triggers a range of intracellular pathways. Psilocybin and major depression Increased network modularity is a symptom of major...

Does genes impact psychedelic experiences?

Mar 8, 2023

Variations in a crucial receptor’s genetics led to differences in efficacy and potency for four psychedelic drugs. Researchers in North Carolina have found evidence that people’s genes may affect how they trip on psychedelic drugs. The finding may be a potential...

Breakthrough study discovers that psychedelics breach our neurons

Mar 8, 2023

New research shows psychedelics activate receptors inside brain cells that other compounds, like serotonin, cannot. he clinical evidence for using psychedelics to treat major depressive disorder, PTSD, addiction, and other mental health conditions is building. But...

LSD modulates music-induced imagery via changes in Para hippocampal connectivity

Aug 16, 2022

Results revealed increased PHC-visual cortex (VC) functional connectivity and PHC to VC information flow in the interaction between music and LSD. This latter result correlated positively with ratings of enhanced eyes-closed visual imagery, including imagery of an...

New Tools for Depression

Aug 12, 2022

COULD AN OVERACTIVE IMMUNE SYSTEM make you depressed? In the late 1990s, psychiatrist Andrew Miller and his colleagues began to notice that patients with cancer, cardiovascular disease, obesity and Crohn’s disease—all conditions that cause higher than normal levels of...

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