by EmpathiCSubstanceS | Aug 17, 2022 | Psilocybin Magic Mushroom, Psychedelic Research
PY dose dependently increased scores of all 5D-ASC core dimensions. Only one subject reacted with transient anxiety to HD PY. Compared with PL, MD and HD PY led to a 50% reduction of performance in the FAIR test. “General inactivation”, “emotional...
by EmpathiCSubstanceS | Aug 17, 2022 | Psilocybin Magic Mushroom, Psychedelic Research
We found that a FC state closely corresponding to the fronto-parietal control system was strongly destabilized in the psychedelic state, while transitions toward a globally synchronized FC state were enhanced. These differences between brain state trajectories in...
by EmpathiCSubstanceS | Aug 17, 2022 | Psilocybin Magic Mushroom, Psychedelic Research
CEQ scores were negatively associated with emotional stability scores (the inverse of neuroticism) in Study 1 and positively associated with neuroticism scores in Study 2. Neuroticism may contribute to the strength of challenging experiences with psychedelics in...
by EmpathiCSubstanceS | Aug 17, 2022 | Psilocybin Magic Mushroom, Psychedelic Research
Nine broad categories of phenomenology were identified in the phenomenological analysis of the experience; perceptual changes including visual, auditory and somatosensory distortions, cognitive changes, changes in mood, effects of memory, spiritual or mystical type...
by EmpathiCSubstanceS | Aug 17, 2022 | Psilocybin Magic Mushroom, Psychedelic Research
Psilocybin reduced spontaneous cortical oscillatory power from 1 to 50 Hz in posterior association cortices, and from 8 to 100 Hz in frontal association cortices. Large decreases in oscillatory power were seen in areas of the default-mode network. Independent...
by EmpathiCSubstanceS | Aug 17, 2022 | Psilocybin Magic Mushroom, Psychedelic Research
Here, independent components and seed-based FC analyses revealed increased DMN-TPN FC and so decreased DMN-TPN orthogonality after psilocybin. Increased DMN-TPN FC has been found in psychosis and meditatory states, which share some phenomenological similarities with...
