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Psychedelics Without the Trip Could Be ‘Healing Magic’ for Mental Health

by EmpathiCSubstanceS | Jun 11, 2022 | Addiction, Alcoholism, Anxiety, Ayahuasca, Bipolar Disorder, Cancer, Chronic Pain, Cluster Headaches, Depression, DMT, Kambo

Experiences of Hallucinogen Treatments to Face Fear of Death

by EmpathiCSubstanceS | Feb 2, 2022 | Cancer, Cannabis Marijuana, CBC, Chronic Pain, Cluster Headaches, Depression, DMT, MDMA Sassafras Molly, OCD

From the late 1950s to the early 1970s a novel experimental paradigm was employed to use hallucinogenic drugs to address the existential anxiety, depression and demoralization often experienced by individuals suffering from terminal cancer. In spite of highly...

Psychedelics are more than LSD and Mushrooms.

by EmpathiCSubstanceS | Jan 14, 2022 | Cluster Headaches, Depression, DMT, Kambo, LSD

The main focus on naturally occurring psychedelics has been on a few dozen species identified in North and South America. For example, the Western world knows of roughly 100 species of psychedelic mushrooms. Is this a bias from our bioprospecting or a true...

What Does Psychedelic Therapy Against Traditional Antidepressant Trial Pits Looks Like?

by EmpathiCSubstanceS | Jan 14, 2022 | Cancer, Cannabis Marijuana, Chronic Pain, Depression, LSD, Neuropathy, Pain, Psychotropics

A first-of-its-kind clinical trial has pitted a common antidepressant against psilocybin, the main psychedelic compound found in magic mushrooms. The results, recently published in the New England Journal of Medicine, are decidedly mixed with the primary depression...

Is the Placebo Problem at the Heart of Modern Psychedelic Clinical Research?

by EmpathiCSubstanceS | Jan 13, 2022 | Chronic Pain, Depression, Iboga, Kambo, LSD, MDMA Sassafras Molly, Pain, Parkinson's Disease

Perhaps one of the most important psychedelic science articles published in 2021 came when psychopharmacologist Suresh Muthukumaraswamy and colleagues Anna Forsythe and Thomas Lumley called out the big elephant in the room of psychedelic clinical trials. The...

How the Discovery of Compounds Solves Mystery of Cannabis’ Potency and Pungent Smell?

by EmpathiCSubstanceS | Jan 13, 2022 | Depression, DMT, Iboga, Kambo, NN-Dimethyltryptamine, Pain, Parkinson's Disease

Cannabis is a remarkably understudied plant containing hundreds of novel molecules, many of which are yet to be scientifically cataloged. This new study set out to investigate what chemicals are responsible for the plant’s characteristic skunk-like smell. The...
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This community is being designed as a secure space. It is not a place to seek, encourage, or participate in the procurement of controlled substances. Do not bring, buy, sell, transfer, or arrive on any illegal substances, or swap information on how to buy them. Attendees and/or members of this community who violate these basic house rules will be removed from the community and will not be allowed to attend future events.

Psychedelic Research

MDMA-assisted psychotherapy for posttraumatic stress disorder in military veterans, firefighters, and police officers: a randomized, double-blind, dose-response, phase 2 clinical trial

Aug 17, 2022

Between Nov 10, 2010, and Jan 29, 2015, 26 veterans and first responders met eligibility criteria and were randomly assigned to receive 30 mg (n=7), 75 mg (n=7), or 125 mg (n=12) of MDMA plus psychotherapy. At the primary endpoint, the 75 mg and 125 mg groups had...

A randomized, controlled pilot study of MDMA-assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD)

Aug 17, 2022

We found that MDMA-assisted psychotherapy can be safely administered in a clinical setting. No drug-related serious adverse events occurred. We did not see statistically significant reductions in CAPS scores (p = 0.066), although there was clinically and statistically...

The Entropic Brain: A Theory of Conscious States Informed by Neuroimaging Research with Psychedelic Drugs

Aug 17, 2022

Based on neuroimaging data with psilocybin, a classic psychedelic drug, it is argued that the defining feature of ‘primary states’ is elevated entropy in certain aspects of brain function, such as the repertoire of functional connectivity motifs that form and fragment...

Psychedelic Medicine

Do we need a mystical experience to have the healing effect?

Jan 1, 2024

The sense of oneness with the universe around you, ego transcendence, feeling that this other reality is more real than your waking reality. It’s certainly the best, most replicated thing in science that if you have the mystical experience during the psychedelic...

Psychedelic versus SSRI

Jan 1, 2024

The standard antidepressants, we know what they do. Brain imaging studies show they very rapidly turn down the danger center in the brain. So you wander around for a few weeks, feel better about things, you smile a little bit more, and then people smile back at you....

What It’s Like to Take a Psychedelic Trip

Jan 1, 2024

It doesn’t take a third eye to see that, at long last, Americans seem primed to turn on. If you’ve heard yourself utter the phrase “plant medicine” when what you mean is “shrooms,” if you’ve found yourself absently Googling “ayahuasca retreats” the way you used to...

Why Psychedelics Are Popular Now

Dec 8, 2023

Has anyone else noticed that health and wellness has become hip? Instead of the old tropes such as football players not trying in school and partying until you are sick made someone popular, now environmental awareness, treating your body as a temple and expanding...

Pineal Gland and DMT (Dimethyltryptamine)

Sep 2, 2023

In the past few years, thrill-seekers from Hollywood, Silicon Valley and beyond have been travelling to South America to take part in so-called Ayahuasca retreats. Their goal: to partake in a brewed concoction made from a vine plant Banisteriopsis caapi, traditionally...

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