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Microdosing VS. Macrodosing (Shamanic Dose) for Anxiety

by EmpathiCSubstanceS | Jun 11, 2022 | Addiction, Alcoholism, Anxiety, Ayahuasca, Bipolar Disorder, Psychotropics, PTSD

Macrodosing has received the most attention in the past several decades, and refers to a full dose of psychedelics that induces a profound state of altered consciousness (typically called “tripping”). As interest in psychedelic therapy has reemerged, some proponents...

How Psychedelic Use Works for Anxiety

by EmpathiCSubstanceS | Jun 11, 2022 | Addiction, Alcoholism, Anxiety, Ayahuasca, Bipolar Disorder

While our largely Westernized views on health and wellness tend to minimize (or outright ignore) the connection between the physical and the ethereal, a growing community of people are recognizing the necessity of the mind-body connection for overall wellness. If our...

The Neurobiology of Anxiety

by EmpathiCSubstanceS | Jun 11, 2022 | Addiction, Alcoholism, Anxiety, Ayahuasca, Bipolar Disorder

One study, published in the journal Cell Report, found that psychedelics enhance neuroplasticity at the cellular level. Imaging of neurons after psychedelic therapy showed increased number and activity of synapses, or “connections”, between neurons. In a way, calling...

How Effective is Treating OCD with Psychedelic Mushrooms?

by EmpathiCSubstanceS | Jun 11, 2022 | Addiction, Alcoholism, Anxiety

OCD, short for obsessive compulsive disorder, is a psychological disorder that cloaks its subjects in cyclical patterns of unwelcome thoughts and all-consuming fears. This intrusive background chatter falcons over its prey, ineluctably leading them to engage in...

Psychedelics Without the Trip Could Be ‘Healing Magic’ for Mental Health

by EmpathiCSubstanceS | Jun 11, 2022 | Addiction, Alcoholism, Anxiety, Ayahuasca, Bipolar Disorder, Cancer, Chronic Pain, Cluster Headaches, Depression, DMT, Kambo

Beware of Psychedelic Gimmick Investment Ventures.

by EmpathiCSubstanceS | Jan 14, 2022 | Addiction, Alcoholism, Anxiety, Ayahuasca, Bipolar Disorder, Cancer, Cannabis Marijuana, CBC, Chronic Pain

Before you start a psychedelic venture or adventure, keep in mind that there are many psychedelic gimmicks that have long preceded the current “shroom boom.” As Alan Watts is purported to have said, “Anybody who tells you that he has some way of leading you to...
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Psychedelic Research

A qualitative report on the subjective experience of intravenous psilocybin administered in an FMRI environment

Aug 17, 2022

Nine broad categories of phenomenology were identified in the phenomenological analysis of the experience; perceptual changes including visual, auditory and somatosensory distortions, cognitive changes, changes in mood, effects of memory, spiritual or mystical type...

Broadband Cortical Desynchronization Underlies the Human Psychedelic State

Aug 17, 2022

Psilocybin reduced spontaneous cortical oscillatory power from 1 to 50 Hz in posterior association cortices, and from 8 to 100 Hz in frontal association cortices. Large decreases in oscillatory power were seen in areas of the...

Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis

Aug 17, 2022

Here, independent components and seed-based FC analyses revealed increased DMN-TPN FC and so decreased DMN-TPN orthogonality after psilocybin. Increased DMN-TPN FC has been found in psychosis and meditatory states, which share some phenomenological similarities with...

Psychedelic Medicine

What is 5-HT2A receptor?

Mar 8, 2023

The 5-HT2A receptor ("5-HT" = 5-hydroxytryptamine, also known as serotonin) is a widely-expressed Gq-coupled protein receptor (GCPR) that triggers a range of intracellular pathways. Psilocybin and major depression Increased network modularity is a symptom of major...

Does genes impact psychedelic experiences?

Mar 8, 2023

Variations in a crucial receptor’s genetics led to differences in efficacy and potency for four psychedelic drugs. Researchers in North Carolina have found evidence that people’s genes may affect how they trip on psychedelic drugs. The finding may be a potential...

Breakthrough study discovers that psychedelics breach our neurons

Mar 8, 2023

New research shows psychedelics activate receptors inside brain cells that other compounds, like serotonin, cannot. he clinical evidence for using psychedelics to treat major depressive disorder, PTSD, addiction, and other mental health conditions is building. But...

LSD modulates music-induced imagery via changes in Para hippocampal connectivity

Aug 16, 2022

Results revealed increased PHC-visual cortex (VC) functional connectivity and PHC to VC information flow in the interaction between music and LSD. This latter result correlated positively with ratings of enhanced eyes-closed visual imagery, including imagery of an...

New Tools for Depression

Aug 12, 2022

COULD AN OVERACTIVE IMMUNE SYSTEM make you depressed? In the late 1990s, psychiatrist Andrew Miller and his colleagues began to notice that patients with cancer, cardiovascular disease, obesity and Crohn’s disease—all conditions that cause higher than normal levels of...

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