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The Entropic Brain: A Theory of Conscious States Informed by Neuroimaging Research with Psychedelic Drugs

by EmpathiCSubstanceS | Aug 17, 2022 | Psilocybin Magic Mushroom, Psychedelic Research

Based on neuroimaging data with psilocybin, a classic psychedelic drug, it is argued that the defining feature of ‘primary states’ is elevated entropy in certain aspects of brain function, such as the repertoire of functional connectivity motifs that form and fragment...

Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose–effect study

by EmpathiCSubstanceS | Aug 17, 2022 | Psilocybin Magic Mushroom, Psychedelic Research

PY dose dependently increased scores of all 5D-ASC core dimensions. Only one subject reacted with transient anxiety to HD PY. Compared with PL, MD and HD PY led to a 50% reduction of performance in the FAIR test. “General inactivation”, “emotional...

Altered trajectories in the dynamical repertoire of functional network states under psilocybin

by EmpathiCSubstanceS | Aug 17, 2022 | Psilocybin Magic Mushroom, Psychedelic Research

We found that a FC state closely corresponding to the fronto-parietal control system was strongly destabilized in the psychedelic state, while transitions toward a globally synchronized FC state were enhanced. These differences between brain state trajectories in...

Neuroticism is associated with challenging experiences with psilocybin mushrooms

by EmpathiCSubstanceS | Aug 17, 2022 | Psilocybin Magic Mushroom, Psychedelic Research

CEQ scores were negatively associated with emotional stability scores (the inverse of neuroticism) in Study 1 and positively associated with neuroticism scores in Study 2. Neuroticism may contribute to the strength of challenging experiences with psychedelics in...

A qualitative report on the subjective experience of intravenous psilocybin administered in an FMRI environment

by EmpathiCSubstanceS | Aug 17, 2022 | Psilocybin Magic Mushroom, Psychedelic Research

Nine broad categories of phenomenology were identified in the phenomenological analysis of the experience; perceptual changes including visual, auditory and somatosensory distortions, cognitive changes, changes in mood, effects of memory, spiritual or mystical type...
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Psychedelic Research

Double-blind comparison of the two hallucinogens psilocybin and dextromethorphan: similarities and differences in subjective experiences

Aug 17, 2022

High doses of both drugs produced similar increases in participant ratings of peak overall drug effect strength, with similar times to maximal effect and time-course. Psilocybin produced orderly dose-related increases on most participant-rated subjective measures...

Long-term follow-up of psilocybin-facilitated smoking cessation

Aug 17, 2022

All 15 participants completed a 12-month follow-up, and 12 (80%) returned for a long-term (≥16 months) follow-up, with a mean interval of 30 months (range = 16-57 months) between target-quit date (i.e., first psilocybin session) and long-term follow-up. At 12-month...

Psilocybin-occasioned mystical-type experience in combination with meditation and other spiritual practices produces enduring positive changes in psychological functioning and in trait measures of prosocial attitudes and behaviors

Aug 17, 2022

Outcomes at 6 months included rates of spiritual practice and persisting effects of psilocybin. Compared with low-dose, high-dose psilocybin produced greater acute and persisting effects. At 6 months, compared with LD-SS, both high-dose groups showed large significant...

Psychedelic Medicine

Are you ready to change your mind?

Jul 21, 2022

For decades, psychedelics have evoked a freewheeling past, calling to mind images of hippie counterculture and swirly neon patterns. Recently, however, psychedelics have become synonymous with serious, forward-looking science. Researchers at renowned institutions are...

How To Change Your Mind

Jul 21, 2022

Based on the book about psychedelic therapy, a new Netflix docu-series prompted another writer to reach out to Pollan — and dig into his own experiences.In late 2012, the best-selling author and journalist Michael Pollan (“The Omnivore’s Dilemma”) was at a dinner...

How to have a safe psychedelic Journey?

Jul 11, 2022

Remember that psychedelic substances are illegal in most jurisdictions. If you have physical or mental health issues, speak to a mental health professional before experimenting with psychedelics. Ensure you are in a physically safe, controlled environment. Always...

Which Are Natural Psychedelics?

Jul 5, 2022

What are the most common natural psychedelics? The natural world is full of psychedelic and other psychoactive substances. In fact, most synthetic psychedelics are derived or inspired by naturally-occurring substances. Many natural psychedelics are considered...

What are the benefits of consuming psilocybin magic mushrooms?

Jul 2, 2022

There are many benefits to consuming psilocybin magic mushrooms, and they have been used in many cultures around the world for thousands of years. Studies have shown “a single dose of psilocybin produced substantial and enduring decreases in depressed mood and anxiety...

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