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Psychedelics not linked to mental health problems or suicidal behavior: A population study

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

After adjusting for sociodemographics, other drug use and childhood depression, we found no significant associations between lifetime use of psychedelics and increased likelihood of past year serious psychological distress, mental health treatment, suicidal thoughts,...

Powerful substances in tiny amounts: An interview study of psychedelic microdosing

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

Respondents tended to experiment with microdosing in phases, reporting mostly positive consequences from this form of drug use. Reported effects included improved mood, cognition, and creativity, which often served to counteract symptoms especially from conditions of...

Neurosciences and psychotherapeutic applications in the psychedelic research renaissance

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

Psilocybin, a 5-HT2A receptor agonist has been associated with reduced activity in the Default- Mode Network (commonly activated during introspection and self-reflection), enhanced access to biographical memories, positive emotional attentional bias and a reduction on...

Altered Insula Connectivity under MDMA

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

Results revealed decreased right insula/salience network functional connectivity under MDMA. Furthermore, these decreases in right insula/salience network connectivity correlated with baseline trait anxiety and acute experiences of altered bodily sensations under...

Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

For the interaction of OBN and DED with Time (QIDS-SR as dependent variable), the main effect and the effects at each time point compared to baseline were all significant (p = 0.002 and p = 0.003, respectively, for main effects), confirming our main hypothesis....
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IMPORTANT NOTICE:

This community is being designed as a secure space. It is not a place to seek, encourage, or participate in the procurement of controlled substances. Do not bring, buy, sell, transfer, or arrive on any illegal substances, or swap information on how to buy them. Attendees and/or members of this community who violate these basic house rules will be removed from the community and will not be allowed to attend future events.

Psychedelic Research

Increased amygdala responses to emotional faces after psilocybin for treatment-resistant depression

Aug 11, 2022

Group results revealed rapid and enduring improvements in depressive symptoms post psilocybin. Increased responses to fearful and happy faces were observed in the right amygdala post-treatment, and right amygdala increases to fearful versus neutral faces were...

Psilocybin with psychological support for treatment-resistant depression: six-month follow-up

Aug 11, 2022

Treatment was generally well tolerated. Relative to baseline, marked reductions in depressive symptoms were observed for the first 5 weeks post-treatment (Cohen's d = 2.2 at week 1 and 2.3 at week 5, both p < 0.001); nine and four patients met the criteria for...

Patients’ Accounts of Increased “Connectedness” and “Acceptance” After Psilocybin for Treatment-Resistant Depression

Aug 11, 2022

Two main change processes were identified in relation to the treatment. The first concerned change from disconnection (from self, others, and world) to connection, and the second concerned change from avoidance (of emotion) to acceptance. A third theme concerned...

Psychedelic Medicine

Agony &

Jul 20, 2018

As human beings, we are hardwired to experience Ecstasy, Epiphany, Laughter and Bliss. Little children twirling in the summer sun to experience the altered state of becoming falling-down-dizzy are not very far removed from whirling dervishes seeking spiritual...

Meditation and Psychedelics

May 2, 2018

By Vanja Palmers Both meditation and psychedelics are close to my heart. I’m grateful to both of them for having shown me that true essence of the heart, which is the heart of everyone and everything, our ultimate belonging and source of meaning. For starters,...

Can a Single Pill Change Your Life?

Apr 25, 2018

MDMA, the active ingredient in the drug Ecstasy, has been reviled as a menace and even a killer. Now some therapists claim it can help light the way out of a traumatic past. Sarah lived in a basement for a few weeks when she was a child. But in a way, she lived there...

Nicholas Powers Ph.D. – Psychedelics, Race, Where They Intersect, and Where They Don’t

Feb 2, 2018

Podcast Show Topics Diversity in research Monica Williams – Diversity in the psychedelic research The trust between diverse populations and institutional research History of forced sterilizations and the Tuskegee syphilis study The importance of storytelling and...

Is Ayahuasca an Antidote to Modern Life?

Feb 2, 2018

Jeremy Narby, Ph.D. In 1995 I published a book called The Cosmic Serpent that dealt with ayahuasca and other subjects. The enthusiasm of many readers took me by surprise. In the book I describe ayahuasca as foul-tasting and my experience drinking it as an ordeal...

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