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Ayahuasca: Pharmacology, neuroscience and therapeutic potential

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

Based on the available evidence, we conclude that ayahuasca shows promise as a therapeutic tool by enhancing self-acceptance and allowing safe exposure to emotional events. We postulate that ayahuasca could be of use in the treatment of impulse-related, personality...

MDMA-assisted psychotherapy for PTSD: Are memory reconsolidation and fear extinction underlying mechanisms?

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

In summary, this review has provided evidence that the beneficial synergistic effects of MDMA with psychotherapy are attributed, at least in part, to the complex neuropharmacological profile of this entactogen creating a neural setting primed to facilitate new...

Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose–effect study

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

PY dose dependently increased scores of all 5D-ASC core dimensions. Only one subject reacted with transient anxiety to HD PY. Compared with PL, MD and HD PY led to a 50% reduction of performance in the FAIR test. “General inactivation”, “emotional...

Safety, Tolerability, and Efficacy of Psilocybin in 9 Patients With Obsessive-Compulsive Disorder

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

One subject experienced transient hypertension without relation to anxiety or somatic symptoms, but no other significant adverse effects were observed. Marked decreases in OCD symptoms of variable degrees were observed in all subjects during 1 or more of the testing...

Replication and extension of a model predicting response to psilocybin

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

This study replicated the previous model, finding a state of surrender before ingestion a key predictor of optimal experience and preoccupation a key predictor of adverse experience. Additional predictors added to the explanatory power for optimal and adverse...
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This community is being designed as a secure space. It is not a place to seek, encourage, or participate in the procurement of controlled substances. Do not bring, buy, sell, transfer, or arrive on any illegal substances, or swap information on how to buy them. Attendees and/or members of this community who violate these basic house rules will be removed from the community and will not be allowed to attend future events.

Psychedelic Research

The hidden therapist: evidence for a central role of music in psychedelic therapy

Aug 11, 2022

Analyses of the interviews revealed that the music had both "welcome" and "unwelcome" influences on patients' subjective experiences. Welcome influences included the evocation of personally meaningful and therapeutically useful emotion and mental imagery, a sense of...

Increased nature relatedness and decreased authoritarian political views after psilocybin for treatment-resistant depression

Aug 11, 2022

Nature relatedness significantly increased (t(6)=−4.242, p=0.003) and authoritarianism significantly decreased (t(6)=2.120, p=0.039) for the patients 1 week after the dosing sessions. At 7–12 months post-dosing, nature relatedness remained significantly increased...

Natural speech algorithm applied to baseline interview data can predict which patients will respond to psilocybin for treatment-resistant depression

Aug 11, 2022

Speech analytics and machine learning successfully differentiated depressed patients from healthy controls and identified treatment responders from non-responders with a significant level of 85% of accuracy (75% precision). Conclusions: Automatic natural language...

Psychedelic Medicine

Psilocybin Mushrooms in Culture and Consciousness

Apr 8, 2020

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Legal Psychedelic Psychotherapy

Apr 8, 2020

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What Are the Medicinal and Spiritual Benefits of Psilocybin Mushrooms?

Nov 25, 2019

Psilocybin cubensis, a psychedelic species of fungi commonly known as “magic mushrooms,” has been part of human culture for thousands of years. Known to both ancient cultures and to modern science as being able to reliably produce a mystical experience, these...

Kicking the Habit: Psilocybin Mushrooms Proven to Help Long-Term Smokers Quit

Nov 25, 2019

We’ve come a long way from doctors endorsing cigarettes and authority figures saying that nicotine is perfectly safe, but even in this day and age when we know that tobacco is the single leading cause of preventable death,[1. CDC Tobacco Fact Sheet:...

FDA Approves Magic Mushrooms For Treating Depression

Sep 1, 2018

The Food and Drug Administration has taken an active role in approving new therapies to treat depression this week. On August 23, the Inquisitr reported that the FDA approved a new form of transcranial magnetic stimulation to help ease treatment-resistant depression....

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