The study found that high doses of ketamine can cause a complete shutdown of EEG activity, which could explain the “state of complete oblivion” associated with a K-hole.
Veterinary medicine has used ketamine as an anesthetic and analgesic for years. Recently, however, researchers have discovered that it can be an effective treatment for depression and PTSD. Previous research on this dissociative drug has focused on its anesthetic properties, which are fairly well understood at this point, but “the effects of ketamine on brain activity have rarely been probed,” the study authors explain.