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What is 5-HT2A receptor?

by SpiSafConf | Mar 8, 2023 | Addiction, Alcoholism, Anxiety, Pain, Psilocybin Magic Mushroom, Psychedelic Medicine, Psychotropics, PTSD

The 5-HT2A receptor (“5-HT” = 5-hydroxytryptamine, also known as serotonin) is a widely-expressed Gq-coupled protein receptor (GCPR) that triggers a range of intracellular pathways. Psilocybin and major depression Increased network modularity is a symptom...

Does genes impact psychedelic experiences?

by SpiSafConf | Mar 8, 2023 | Addiction, Alcoholism, Anxiety, DMT, Iboga, LSD, Psychedelic Medicine

Variations in a crucial receptor’s genetics led to differences in efficacy and potency for four psychedelic drugs. Researchers in North Carolina have found evidence that people’s genes may affect how they trip on psychedelic drugs. The finding may be a potential...

Breakthrough study discovers that psychedelics breach our neurons

by SpiSafConf | Mar 8, 2023 | Addiction, Alcoholism, Ayahuasca, Psychedelic Medicine

New research shows psychedelics activate receptors inside brain cells that other compounds, like serotonin, cannot. he clinical evidence for using psychedelics to treat major depressive disorder, PTSD, addiction, and other mental health conditions is building. But...

New Tools for Depression

by SpiSafConf | Aug 12, 2022 | Bipolar Disorder, Chronic Pain, Kambo, LSD, MDMA Sassafras Molly, Microdosing, NN-Dimethyltryptamine, OCD, Psilocybin Magic Mushroom, Psychedelic Medicine

COULD AN OVERACTIVE IMMUNE SYSTEM make you depressed? In the late 1990s, psychiatrist Andrew Miller and his colleagues began to notice that patients with cancer, cardiovascular disease, obesity and Crohn’s disease—all conditions that cause higher than normal levels of...

What are selective serotonin reuptake inhibitor SSRIs antidepressants

by SpiSafConf | Aug 4, 2022 | Addiction, Anxiety, Ayahuasca, Bipolar Disorder, Chronic Pain, MDMA Sassafras Molly, Psychedelic Medicine, Psychotropics

Serotonin is one of the chemical messengers (neurotransmitters) that carry signals between brain nerve cells (neurons). SSRIs block the reabsorption (reuptake) of serotonin into neurons. This makes more serotonin available to improve transmission of messages between...
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Psychedelic Research

The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level–Dependent Resting State Functional Connectivity.

Aug 17, 2022

Marked increases in positive mood were produced by MDMA. Decreased CBF only was observed after MDMA, and this was localized to the right medial temporal lobe (MTL), thalamus, inferior visual cortex, and the somatosensory cortex. Decreased CBF in the right amygdala and...

The effect of acutely administered MDMA on subjective and BOLD-fMRI responses to favorite and worst autobiographical memories

Aug 17, 2022

Favorite memories were rated as significantly more vivid, emotionally intense and positive after MDMA than placebo and worst memories were rated as less negative. Functional MRI data from 17 participants showed robust activations to AMs in regions known to be involved...

Durability of improvement in post-traumatic stress disorder symptoms and absence of harmful effects or drug dependency after MDMA psychotherapy: a prospective longterm follow-up study

Aug 17, 2022

Results for the 16 CAPS completers showed there were no statistical differences between mean CAPS score at LTFU (mean = 23.7; SD = 22.8) (tmatched = 0.1; df = 15, p = 0.91) and the mean CAPS score previously obtained at Study Exit (mean = 24.6, SD = 18.6). On average,...

Psychedelic Medicine

Pineal Gland and DMT (Dimethyltryptamine)

Sep 2, 2023

In the past few years, thrill-seekers from Hollywood, Silicon Valley and beyond have been travelling to South America to take part in so-called Ayahuasca retreats. Their goal: to partake in a brewed concoction made from a vine plant Banisteriopsis caapi, traditionally...

Psychedelic Use Statistics

Sep 2, 2023

With scientific progress marching on and psychedelic use among adults exploding, the need for creating infrastructure and delivering safe and legal access is already upon us. Recently published data from the annual Monitoring the Future (MTF) survey by the National...

Neuroplasticity Explained

Sep 2, 2023

A quarter of the world’s population is estimated to be affected by mental health or neurological challenges in their lifetime. In 2014, approximately 20% of U.S. adults had a mental illness and 22.5 million Americans aged 12 or older were in need of treatment for...

Mental Health Treatment Options

Sep 2, 2023

A quarter of the world’s population is estimated to be affected by mental health or neurological challenges in their lifetime. In 2014, approximately 20% of U.S. adults had a mental illness and 22.5 million Americans aged 12 or older were in need of treatment for...

Improving the End of Life Experience with Entheogens

Sep 2, 2023

:::In a 2019 study, 55% of families felt their loved one had a “bad death.” By igniting a movement to spark conversations and ask the right questions, we create opportunities for the things people most want – including spending time with those they love, dignity, and...

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