N,N-dimethyltryptamine and the pineal gland: Separating fact from myth.

by SpiSafConf | Aug 16, 2022 | Psychedelic Research

It is clear that very minute concentrations of N,Ndimethyltryptamine have been detected in the brain, but they are not sufficient to produce psychoactive effects. Alternative explanations are presented to explain how stress and near death can produce altered states of...

Neural correlates of the DMT experience as assessed via multivariate EEG

by SpiSafConf | Aug 16, 2022 | Psychedelic Research

Compared with placebo, DMT markedly reduced oscillatory power in the alpha and beta bands and robustly increased spontaneous signal diversity. Time-referenced analyses revealed close relationships between changes in various aspects of subjective experience and changes...

DMT Models the Near-Death Experience

by SpiSafConf | Aug 16, 2022 | Psychedelic Research

Results revealed significant increases in phenomenological features associated with the NDE, following DMT administration compared to placebo. Also, we found significant relationships between the NDE scores and DMT-induced ego-dissolution and mystical-type...

Intensity of Mystical Experiences Occasioned by 5-MeO-DMT and Comparison With a Prior Psilocybin Study

by SpiSafConf | Aug 16, 2022 | Psychedelic Research

Administration of 5-MeO-DMT occasioned strong mystical experiences (MEQ30 Overall Mintensity = 4.17, ± 0.64, range 0–5) and the majority (75%) had “a complete mystical experience” (≥60% on all MEQ30 subscales). Compared to a prior laboratory-based psilocybin study,...

Neural correlates of the DMT experience assessed with multivariate EEG

by SpiSafConf | Aug 16, 2022 | Psychedelic Research

Compared with placebo, DMT markedly reduced oscillatory power in the alpha and beta bands and robustly increased spontaneous signal diversity. Time-referenced and neurophenomenological analyses revealed close relationships between changes in various aspects of...