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Neural Correlates of the Entheogen State as Determined by fMRI Studies with Psilocybin

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

As predicted, profound changes in consciousness were observed after psilocybin, but surprisingly, only decreases in cerebral blood flow and BOLD signal were seen, and these were maximal in hub regions, such as the thalamus and anterior and posterior cingulate cortex...

Decreased mental time travel to the past correlates with default-mode network disintegration under lysergic acid diethylamide

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

Results revealed significantly fewer mental spaces for the past under LSD and this effect correlated with the general intensity of the drug’s subjective effects. No differences in the number of mental spaces for the present or future were observed. Consistent with the...

Acute MDMA administration modulates neural and behavioral measures of self-referential processing

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

MDMA specifically reduces processing of negative self-referential information in the frontal lobe. Effects in the insula are more general, and reductions are seen in both self and other evaluations. This may suggest a potential novel clinical use for MDMA in treating...

Ibogaine treatment outcomes for opioid dependence from a twelve-month follow-up observational study

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

Nonparametric comparisons via Friedman Test between baseline and 12-month follow-up for participants completing all interviews (n = 8) showed a significant reduction for the ASI-Lite drug use (p = 0.002) composite score. Reductions in BDI-II scores from baseline to...

Psychiatry’s next top model: Cause for a re-think on drug models of psychosis and other psychiatric disorders

by EmpathiCSubstanceS | Aug 11, 2022 | Psychedelic Research

In the first part, mental health professionals associated statements referring to specific experiences, for example ‘I don’t bother to get out of bed’, to one or more psychiatric symptom clusters, for example depression and negative psychotic...
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This community is being designed as a secure space. It is not a place to seek, encourage, or participate in the procurement of controlled substances. Do not bring, buy, sell, transfer, or arrive on any illegal substances, or swap information on how to buy them. Attendees and/or members of this community who violate these basic house rules will be removed from the community and will not be allowed to attend future events.

Psychedelic Research

MDMA-assisted psychotherapy for posttraumatic stress disorder in military veterans, firefighters, and police officers: a randomized, double-blind, dose-response, phase 2 clinical trial

Aug 17, 2022

Between Nov 10, 2010, and Jan 29, 2015, 26 veterans and first responders met eligibility criteria and were randomly assigned to receive 30 mg (n=7), 75 mg (n=7), or 125 mg (n=12) of MDMA plus psychotherapy. At the primary endpoint, the 75 mg and 125 mg groups had...

A randomized, controlled pilot study of MDMA-assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD)

Aug 17, 2022

We found that MDMA-assisted psychotherapy can be safely administered in a clinical setting. No drug-related serious adverse events occurred. We did not see statistically significant reductions in CAPS scores (p = 0.066), although there was clinically and statistically...

The Entropic Brain: A Theory of Conscious States Informed by Neuroimaging Research with Psychedelic Drugs

Aug 17, 2022

Based on neuroimaging data with psilocybin, a classic psychedelic drug, it is argued that the defining feature of ‘primary states’ is elevated entropy in certain aspects of brain function, such as the repertoire of functional connectivity motifs that form and fragment...

Psychedelic Medicine

Do we need a mystical experience to have the healing effect?

Jan 1, 2024

The sense of oneness with the universe around you, ego transcendence, feeling that this other reality is more real than your waking reality. It’s certainly the best, most replicated thing in science that if you have the mystical experience during the psychedelic...

Psychedelic versus SSRI

Jan 1, 2024

The standard antidepressants, we know what they do. Brain imaging studies show they very rapidly turn down the danger center in the brain. So you wander around for a few weeks, feel better about things, you smile a little bit more, and then people smile back at you....

What It’s Like to Take a Psychedelic Trip

Jan 1, 2024

It doesn’t take a third eye to see that, at long last, Americans seem primed to turn on. If you’ve heard yourself utter the phrase “plant medicine” when what you mean is “shrooms,” if you’ve found yourself absently Googling “ayahuasca retreats” the way you used to...

Why Psychedelics Are Popular Now

Dec 8, 2023

Has anyone else noticed that health and wellness has become hip? Instead of the old tropes such as football players not trying in school and partying until you are sick made someone popular, now environmental awareness, treating your body as a temple and expanding...

Pineal Gland and DMT (Dimethyltryptamine)

Sep 2, 2023

In the past few years, thrill-seekers from Hollywood, Silicon Valley and beyond have been travelling to South America to take part in so-called Ayahuasca retreats. Their goal: to partake in a brewed concoction made from a vine plant Banisteriopsis caapi, traditionally...

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