What It’s Like to Trip on DMT

Everything to know about the hallucinogenic “spirit molecule”—common side effects include seeing aliens and finally connecting with the universe. When Jonathan Bell first tried DMT, he was already well-acquainted with psychedelics—at 34, he had taken acid and used...

What do we know about how hallucinogens work on the brain to produce subjective effects?

This question can be approached from a number of different levels. At the lowest functionally relevant level, how do the hallucinogenic compounds themselves interact with a certain neurotransmitter receptor to alter neuronal activity? Then at the neuronal population...

Is the Phase 3 Trial Data for MDMA Therapy sets Path for FDA Approval?

The first results from Phase 3 trials testing MDMA-assisted psychotherapy for post-traumatic stress disorder (PTSD) have been announced. The extremely promising data are the first Phase 3 results to be revealed for any psychedelic-based therapy, paving the way for a...

What Does Psychedelic Therapy Against Traditional Antidepressant Trial Pits Looks Like?

A first-of-its-kind clinical trial has pitted a common antidepressant against psilocybin, the main psychedelic compound found in magic mushrooms. The results, recently published in the New England Journal of Medicine, are decidedly mixed with the primary depression...