5-Methoxy-N,N-dimethyltryptamine (commonly known as 5-MeO-DMT) is a naturally occurring psychedelic substance of the tryptamine class. As with its structural relatives DMT and 5-HO-DMT (Bufotenin), 5-MeO-DMT has been used as an entheogen by South American shamans for thousands of years[citation needed] and has recently been demonstrated to induce mystical experiences.

It is distributed in a wide variety of plant species, as well as in the venom of a single psychoactive toad species (Bufo Alvaris). It has also been shown to be produced endogenously in the human body in trace amounts, although its biological function is unclear.

In modern times, 5-MeO-DMT is primarily acquired and consumed in its synthetic powder form through the use of online research chemical vendors. When taken in its synthetic powder form, 5-MeO-DMT is typically vaporized, but can also be insufflated (although this is discouraged), and is active at a dose of as little as 2 mg. It has been suggested that it possesses roughly 4-5x the potency of DMT.

As with DMT, 5-MeO-DMT has been demonstrated to be active orally when taken with an MAOI, but according to numerous reports this combination tends to be extremely unpleasant, producing a strong body load in addition to the risk of hypertensive symptoms and serotonin syndrome, and is therefore strongly advised against.[4] On both physical and psychological levels, it is considered to be substantially less safe than DMT.[citation needed]

Anecdotal reports indicate that this substance is likely to be overly intense for those who are not already extensively experienced with hallucinogens, specifically powerful psychedelic tryptamines like DMT, ayahuasca and DPT. Therefore it is highly advised to approach this very unpredictable, and powerful hallucinogenic substance with the proper amount of precaution, preparation, and harm reduction practices if one chooses to use it.

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